Refers to health outcomes that patients experience across the variety of real-world settings, including: survival, functional status, quality of life, quality of death, symptoms, pain, nausea, psychosocial well-being, health utility (patient-perceived value of particular states of health), and patient satisfaction. (Excluded are outcomes that patients do not directly experience, such as blood pressure, lipid levels, bone density, viral load, or cardiac output.) Patient-centered outcomes can be assessed at a generic level or a disease/condition-specific level.