Objective : The client is committed to advancing care for patients around the world by bringing forward medicines in areas of unmet medical need. They do this through internal research and development, as well as through collaborations with academic and industry partners. The innovative product has a compelling clinical benefit for which a cost-effectiveness analysis is needed to generate complementary value messages. Results of a cost-effectiveness analysis served to inform pricing decisions, motivate changes in medicine benefits packages, and shape local clinical practice.