The formulation of an evidence question based on: Population (e.g., condition, disease severity/stage, comorbidities, risk factors, demographics), Intervention (e.g., technology type, regimen/dosage/frequency, technique/method of administration), Comparator (e.g., placebo, usual/standard care, active control), Outcomes (e.g., morbidity, mortality, quality of life, adverse events), Timing (e.g., duration/intervals of follow-up), and Setting (e.g., primary, inpatient, specialty, home care).